Precision phenotyping of emphysema in the elderly: the MESA Lung Study
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 08/2004
End Date: 01/2027
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
- Improve methods for earliest detection and diagnosis and develop effective strategies for preventing the onset and progression of COPD
- Develop personalized medicine for COPD based on the pathogenesis and clinical heterogeneity
- Promote research that can lead to strategies that help prevent the onset and progression of COPD and improve the quality of COPD care and management
Collaboration: Columbia University Health Sciences
Activity Type: Research
Activity Description
This NHLBI-funded research activity is being carried out by Columbia University Health Sciences.Chronic obstructive pulmonary disease (COPD) and emphysema are, jointly, the fourth leading cause of death in the United States and third leading cause globally. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study found that emphysema measured quantitatively on computed tomography (CT) is common and morbid among older adults in the general population; however, standard measures underestimate the complexity of the disease. In this renewal, we hypothesize that machine-learned CT emphysema subtypes are distinct, have different causes and prognoses, and that distinguishing pathological emphysema from that resulting from normal aging with help the prevention and treatment of COPD and emphysema.
Audience
General Audience: Health professionals, Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
This activity was funded through the National Heart, Lung, and Blood Institute.Impact Analysis
Results of program are in progressAdvice or Lessons Learned
In processContact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland