The Role of HuR in HIV related COPD
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 02/2022
End Date: 06/2026
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
- Improve methods for earliest detection and diagnosis and develop effective strategies for preventing the onset and progression of COPD
- Promote research that can lead to strategies that help prevent the onset and progression of COPD and improve the quality of COPD care and management
Collaboration: Suny Downstate Medical Center
Activity Type: Research
Activity Description
This NHLBI-funded research activity is being carried out by Suny Downstate Medical Center.HIV infection accelerates the development of chronic obstructive pulmonary disease (COPD), which is a leading cause of morbidity and mortality in people living with HIV. The RNA binding protein Human Antigen R (HuR) regulates global expression and supports the production of key repair mediators in the airway epithelium. This proposal will advance public health by determining how cigarette smoke and HIV virus promote airflow obstruction and airway remodeling in HIV by repressing HuR to alter the airway epithelial transcriptome.
Audience
General Audience: Health professionals, Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
This activity was funded through the National Heart, Lung, and Blood Institute.Impact Analysis
Results of program are in progressAdvice or Lessons Learned
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Contact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland