COPD Susceptibility, Heterogeneity, and Progression: Proteomics and Genetics
Overview
Organization: National Heart Lung, and Blood Institute
Start Date: 04/2017
End Date: Ongoing
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Improve methods for earliest detection and diagnosis and develop effective strategies for preventing the onset and progression of COPD
- Define and characterize the pathogenesis of COPD heterogeneity
- Promote research that can lead to strategies that help prevent the onset and progression of COPD and improve the quality of COPD care and management
Collaboration: BRIGHAM AND WOMEN'S HOSPITAL
Activity Type: Research
Activity Description
Chronic obstructive pulmonary disease (COPD) is a major public health problem that is strongly influenced by cigarette smoking and genetic predisposition. The primary objectives of this study are to identify new protein biomarkers for COPD by studying large numbers of lung tissue samples, to determine the genetic determinants of these protein biomarker levels, and to integrate protein biomarkers, genetic variants, gene expression levels, and epigenetic marks to identify biological networks related to COPD pathogenesis. Identification and investigation of novel protein biomarkers may lead to new insights into the biological mechanisms causing COPD, suggest new pathways for treatment, and provide tools to select subjects for future clinical trials of COPD medications.Audience
General Audience: Health professionals, Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
It was funded through the National Heart, Lung and Blood Institute and funds to be allotted to grantees.Impact Analysis
Results of their programs are in progress.Advice or Lessons Learned
In process.Contact Information
National Heart Lung, and Blood Institute
Program Analyst
Bethesda
Maryland