Photochemical Generation of Gas Phase Nitric Oxide from Immobilized S-Nitrosothiols for Biomedical Applications
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 09/2019
End Date: 07/2024
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
- Promote research that can lead to strategies that help prevent the onset and progression of COPD and improve the quality of COPD care and management
Collaboration: Nota Laboratories, LLC.
Activity Type: Research
Activity Description
This NHLBI-funded research activity is being carried out by Nota Laboratories, LLC.Inhaled nitric oxide (iNO) is a well-established therapy for Persistent Pulmonary Hypertension in Neonates (PPHN) due to its vasodilatory and bronchodilatory functionality; currently iNO has been investigated for the treatment of other diseases including cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and bronchiolitis, as these patients are susceptible to respiratory infections, which can progress into recalcitrant biofilms that are highly resistant to traditional antibiotics. There are more than 30,000 CF patients in the United States, and COPD is the third leading cause of death in the U. S. with 16.4 million diagnosed patients, while bronchiolitis is the leading cause of hospitalization for infants under 1 yr of age. Through the efforts described in this application, NOTA Laboratories will continue to advance the development of a simple and portable NO generation devices based on photolysis of immobilized S-nitrosothiol species, eliminating the need for NO gas cylinders, yet capable of delivering 1-200 ppmv NO for vasodilatory and antimicrobial therapies for both hospital and at home use.
Audience
General Audience: Health professionals, Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
This activity was funded through the National Heart, Lung, and Blood Institute.Impact Analysis
Results of program are in progressAdvice or Lessons Learned
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Contact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland