Mapping Airway Epithelial Cell-Immune Cell Interactions in Lung Health and Disease
Overview
Organization: National Heart, Lung and Blood Institute
Start Date: 09/2024
End Date: Ongoing
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
Collaboration: Massachusetts General Hospital
Activity Type: Research
Activity Description
Asthma and chronic obstructive pulmonary disease (COPD) together are the largest causes of disability and death from chronic lung diseases worldwide. One of the key mechanisms causing both diseases is aberrant airway communication between the cells lining the airways in the lung (airway epithelial cells) and cells of the immune system, which leads to inflammation and remodeling of the lungs and airways. Our overall objective is to comprehensively define the signaling and spatial relationships between airway epithelial cells and airway immune cell populations in asthma and COPD to define therapeutic approaches that precisely target disease- specific mechanisms.Audience
General Audience: Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
It was funded through the National Heart, Lung and Blood Institute and funds to be allotted to grantees.Impact Analysis
Results of their programs are in progress.Advice or Lessons Learned
In process.Contact Information
National Heart, Lung and Blood Institute
Program Analyst
Bethesda
Maryland