
Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 05/2024
End Date: Ongoing
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
Collaboration: Brigham and Women's Hospital
Activity Type: Research
Activity Description
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, due to different groups of biologic processes. Genetic variants and small molecules, called metabolites, may help identify these processes and explain differences in COPD. In our study, we will classify groups of genetic variants into pathways, and examine how they relate to metabolites, as well as gene expression and proteins. We will then investigate how this information can be used to subset COPD, identify gene by environment interactions, and identify new drug targets. This work will lead to a greater understanding of disease processes in COPD and more specific treatments.Audience
General Audience: Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
It was funded through the National Heart, Lung and Blood Institute and funds to be allotted to grantees.Impact Analysis
Results of their programs are in progress.Advice or Lessons Learned
In process.Contact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland