Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPD
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 04/2023
End Date: Ongoing
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
Collaboration: Florida International University
Activity Type: Research
Activity Description
COPD is a multifactorial pathology and PLWH demonstrate and higher incidence of COPD even when adjusted for the smoking status. HIV tat and TGF-β signaling (upregulated by Tat, cigarette smoke and in COPD), dysregulate the airway microRNAome and this can have downstream effects on the transcriptome and signaling pathways leading to pathological hallmarks of COPD. Understanding the mechanism of miRNA dysregulation and its downstream effects can identify targets for intervention, and silencing HIV transcription by CRISPR based inactivation of cellular cofactor CyclinT1 only in HIV-infected cells can decrease the Tat burden in the airways and improve outcomes in HIV associated COPD.Audience
General Audience: Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
It was funded through the National Heart, Lung, and Blood Institute and funds to be allotted to grantees.Impact Analysis
Results of their programs are in progress.Advice or Lessons Learned
In process.Contact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland