Airway Basal Progenitor Dysfunction in the Detection, Progression and Pathogenesis of Early COPD
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 09/2023
End Date: Ongoing
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
Collaboration: University of Colorado Denver
Activity Type: Research
Activity Description
Chronic obstructive pulmonary disease (COPD) develops in susceptible smokers over a period of 2-3 decades during which evolving disease remains relatively silent. Although 30-40% of smokers will eventually develop COPD, there are no clinical, physiologic, biologic or molecular measures that identify vulnerable people during the early phase of disease before it can be diagnosed by impaired lung function. The goal of this proposal is to use airway basal stem/progenitor cell dysfunction as a marker to identify vulnerable smokers during early COPD, so that efforts can be focused on primary and secondary prevention, treatments can be developed to slow lung function decline, and early mechanisms of disease can be identified.Audience
General Audience: Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
It was funded through the National Heart, Lung, and Blood Institute and funds to be allotted to grantees.Impact Analysis
Results of their programs are in progress.Advice or Lessons Learned
In process.Related Links
Contact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland