Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
Overview
Organization: National Heart, Lung, and Blood Institute
Start Date: 01/2021
End Date: 12/2024
Primary Goal: Goal 4: Increase and sustain research to better understand the prevention, pathogenesis, diagnosis, treatment, and management of COPD.
Secondary Goal(s):
Objective(s):
- Help expand, coordinate, and optimize COPD research efforts
- Improve methods for earliest detection and diagnosis and develop effective strategies for preventing the onset and progression of COPD
- Define and characterize the pathogenesis of COPD heterogeneity
- Develop personalized medicine for COPD based on the pathogenesis and clinical heterogeneity
- Promote research that can lead to strategies that help prevent the onset and progression of COPD and improve the quality of COPD care and management
Collaboration: Brigham and Women's Hospital
Activity Type: Research
Activity Description
This NHLBI-funded research activity is being carried out by Brigham and Women's Hospital.Chronic obstructive pulmonary disease (COPD) is a major public health problem that is strongly influenced by cigarette smoking and genetic predisposition. Although previous studies have identified genomic regions associated with COPD, the networks of interacting genes and proteins that influence COPD have not been identified. We will use protein-protein interaction data to build biological networks related to COPD susceptibility, which will provide new insights into the biological mechanisms causing COPD and suggest new pathways for treatment.
Audience
General Audience: Health professionals, Researchers
Focused Audience: n/a
Program Reach: National
Type of Area: N/A
Setting: Workplace
Cost and Funding Sources
This activity was funded through the National Heart, Lung, and Blood Institute.Impact Analysis
Results of program are in progressAdvice or Lessons Learned
In progressContact Information
National Heart, Lung, and Blood Institute
Program Analyst
Bethesda
Maryland